LARGE-SCALE BIOMARKERS PROJECT
New biomarkers for early detection of Alzheimer’s disease
The direct goal of the project is to improve diagnosis and the possibilities for prevention of Alzheimers dementia. Thus, the perspectives of users, i.e. patients diagnosed with MCI or AD or their relatives/ next of kin, are very important. There are about 130 different organizations for relatives/ next of kin in Norway, most of which are organized through the Norwegian Health Association. In the initial phase of the project, we will arrange for communication with patients organizations to obtain the users’ view of the type and form of information that would be useful to include in the project, and how the project can contribute with information and communication of results. Which form of communication that would be the most useful will be discussed with the Norwegian Health Association, but we envision both meetings with local patient organizations as well as setting up a web-site with opportunities for giving input and responses to the project group.
World-leading national and international researchers within different fields of relevance to Alzheimer research work together in a highly cross-discliplinary project that combines basic science with clinical applications and translation to patients, diagnostics and treatment. Supervision shared between UiO and Oslo University Hospital (OUS).
UNDERSTANDING AGING AND ATROPHY
The prevalence of Alzheimer’s Disease (AD) increases sharply from 60 years, reaching about 50% in 90 year olds. At the same time, 50% of healthy elderly report worries about their own memory function. Thus, understanding the neural foundation for cognitive decrements in both demented and healthy aging is among the most important tasks for research in neuroscience. At the heart of this question is the role of amyloid protein in neurodegeneration and memory decline in both AD and healthy aging. Current models hold that the influence of amyloid on the brain is largest in very early phases of AD, years before clinical symptoms become manifest, so it is paradoxical that the influence of amyloid on brain atrophy and memory problems in healthy elderly is little researched and with inconsistent results. Progress is hindered by methodological differences and statistically under-powered studies due to very costly data collection. The main objective of this project is to make a leap forward with researchers at the forefront of aging and AD, by launching a large database including 500 healthy and 500 patients.