Patterns and mechanisms of brain atrophy in healthy aging and dementia
Why is the aging brain susceptible to Alzheimer’s Disease?
Three major symptoms of AD – memory reduction, brain atrophy and amyloid plaques – are also found in healthy elderly. Current models posit a role of amyloid at a very early stage. We argue that AD cannot be understood without understanding its major risk factor: age. We examine elderly with different protective and risk factors compared to early AD.